Reema Zeineldin, Ph.D.
ovarian CSCs have the ability to generate and be propagated in vitro as MCAs. All the above data point to the
important role that MCAs play in aggressiveness, propagation and recurrence of OVCA.
Sensitizing resistant cells:
Studies indicate that inhibitors of adhesion that disperse MCAs sensitize them to chemotherapy. Thus, identifying
compounds that disperse these MCAs would sensitize this resistant subpopulation to chemotherapy.