Reema Zeineldin, Ph.D.
Liposomes are made of phospholipid molecules that spontaneously self-assemble into spherically closed
bilayer membranes, where the polar heads are hydrated with water, whereas the hydrophobic
hydrocarbonchains of each leaflet of the bilayer core interact with each other. The thickness of the lipid bilayer
of the liposomes is typically about 5 nm. Typical phospholipids used to prepare liposomes include phosphatidyl
cholines (PC), phosphatidyl ethanolamines (PE), and phosphatidyl glycerols (PG). In addition, other lipids are
usually incorporated into liposomes such as cholesterol, phosphatidyl inositol (PI), phosphatidyl serine (PS),
and sphingomylin. The phospholipid composition of liposomes defines membrane surface properties; for
highly dependent on presence of charged lipids.